Massively parallel simultaneous profiling of the transcriptomic and epigenomic landscape at single cell resolution
We present here a single cell high-throughput assay to simultaneously profile 3' gene expression and open chromatin via ATAC-seq from the same nucleus. Simultaneous profiling allows for finer resolution of cell types in terminally differentiated cells and cells on a developmental trajectory. This assay has the potential to reveal the complex interplay between regulatory elements, open chromatin, and gene expression.
We present here a single cell high-throughput assay to simultaneously profile 3' gene expression and open chromatin via ATAC-seq from the same nucleus. Simultaneous profiling allows for finer resolution of cell types in terminally differentiated cells and cells on a developmental trajectory. This assay has the potential to reveal the complex interplay between regulatory elements, open chromatin, and gene expression.