Spatially Resolved Whole Transcriptome Molecular Investigation of Triple Positive Breast Cancer FFPE Tumors using the Visium Platform
Triple-positive ductal carcinoma in situ (TPDCIS) is a pre-neoplastic tumor positive for HER2. Such tumors routinely exhibit elevated levels of HER2, along with oncogenic cell surface estrogen and progesterone receptors, but the underlying phenotype and survival rates vary. To better understand TPDCIS heterogeneity, we examined the tumor microenvironment by characterizing the spatial distribution of cellular transcriptomes.
Triple-positive ductal carcinoma in situ (TPDCIS) is a pre-neoplastic tumor positive for HER2. Such tumors routinely exhibit elevated levels of HER2, along with oncogenic cell surface estrogen and progesterone receptors, but the underlying phenotype and survival rates vary. To better understand TPDCIS heterogeneity, we examined the tumor microenvironment by characterizing the spatial distribution of cellular transcriptomes.